Microbiology nerd
Researchers from the University of California San Diego have identified a potential new target against Pseudomonas aeruginosa infections – which could be applied to help treat all gram-negative infections. It was found that by interfering with the Mla pathway in P. aeruginosa, the bacteria became more permeable, and more susceptible to immune components. P. aeruginosa, … Read more
Scientists have found a way to boost the antibacterial activity of an antimicrobial peptide originating from a spider, according to a recent publication in the journal ACS Chemical Biology. With increasing rates of antimicrobial resistance a global concern, scientists are attempting to find alternatives to the traditional antibiotic drugs which we have relied on for … Read more
The bacterial species Klebsiella may contribute to a dangerously high level of antibiotic resistance in Kenya, a recent study suggests. Published in the journal PLOS ONE, the study is a collaborative effort between institutions including the US Naval Research Laboratory (NRL) and the Kenya Medical Research Institute (KEMRI). In many developing nations, the occurrence of … Read more
Could pathogens obtain antibiotic resistance genes from the same organisms that we use to produce our antibiotics? A new study suggests that this could indeed be the case, as resistance genes bearing striking similarity to one another are found in two key groups of microorganisms. In addition, the study resulted in the proposal of a … Read more
The World Health Organisation (WHO) has updated their Essential Medicines List (EML), adding 10 new antibiotics which should be used in adults, and 12 for children. In addition, they’ve also decided to try a new approach to combat antibiotic resistant bacteria by dividing antibiotics into three different categories; access, watch and reserve. It’s hoped that … Read more
A modified form of vancomycin gives the drug key advantages which could greatly boost its efficiency against dangerous bacteria and reduce the chances of resistant strains developing, new research shows. The study, conducted by scientists from The Scripps Research Institute (TSRI) in the US, was published in the journal Proceedings of the National Academy of … Read more
Researchers from the National University of Ireland Galway have developed a new antibacterial treatment, effective against drug-resistant bacteria, which takes inspiration from the human immune system. This treatment, called the ‘iodo-thiocyanate complex’, or ITC for short, also showed a low propensity to lead to the development of resistant bacterial strains. The paper was published on … Read more
Could paper be used to help protect us against dangerous bacteria? New research suggests this could be entirely possible, as a team led by Rutgers University scientists has developed the first paper-based sanitiser. Their work was published in the journal Proceedings of the National Academy of Sciences. The sanitiser paper works by producing ‘plasma’ – … Read more
Researchers have found a method to identify bacteria showing one of the most dangerous forms of antibiotic resistance, in a test that’s both quick and cheap to run. Dr Laurent Dortet, an Associate Professor at South Paris University and his colleagues at Imperial College London, Dr Gerald Larrouy-Maumus and Professor Alain Filloux, presented their work … Read more
The fight against TB has taken several promising steps forward – scientists from Rutgers University have not only uncovered vital new information about how rifampicin, the frontline anti-TB drug, binds to its target, but have also discovered a completely new class of compounds that specifically kill TB bacteria. The paper was published in the journal … Read more